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YOUR CART

Single Cell Technology for Cancer Biology


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Our lab focuses on investigating the underlying molecular mechanisms of rare and aggressive subpopulations of cancer cells, as well as (plastic) cancer cell states that contribute to tumor progression, metastasis, and/or therapy resistance. We employ multidisciplinary technologies with the hope of translating the information we discover into clinical applications.
To achieve these goals, we have developed a range of tools that integrate advanced microscopy and imaging, machine learning- or AI-assisted imaging analysis, single-cell and spatial omics technologies, and bioinformatics.

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Research Topics
Profiling rare & aggressive subpopulations of cancer cells or distinct cancer cell states
DNA damage response and cancer biology
Single-cell spatial omics profiling of tumor heterogeneity
Machine learning-assisted cell fate prediction and target discovery
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