Principal Investigator
(* joint first author)
1. You L.*, Su P.-R.*, Betjes M*. Ghadiri Rad, R., Chou, T.-C., Beerens, C., van Oosten, E., Leufkens, F., Gasecka, P., Muraro, M., van Tol, R., van Steenderen, D., Farooq, S., Hardillo, J., Baatenburg de Jong, R., Brinks, D., Chien, M.-P. "Functional single cell selection and annotated profiling of dynamically changing cancer cells." Accepted, Nature Biomedical Engineering.
2. Li L., Ugalde A. P., Scheele C. LGJ, Dieter S. M., Nagel R., Ma J., Pataskar, A., Korkmaz, G., Elkon R., Chien M.P., You L., Su P. R., Bleijerveld O. B., Altelaar, M., Momchev L., Manber Z., Han R., van Breugel P. C., Lopes R., ten Dijke P., van Rheenen J., Agami R. "A Comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis." Genome Biology, 2021, In press.
Postdoctoral and graduate
(* joint first author)
1. Chien M.P.*, Brinks D.*, Adam, Y., Bloxham, W., Kheifets, S., Cohen A.E. “Two-photon photoactivated voltage imaging in brain tissue.” Science Advances, 2021, In press (BioRxiv, doi: https://doi.org/10.1101/211946)
2. Werley C.A., Chien M.P., Cohen A.E. “An ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation.” Biomedical Optics Express. 2017, 8(12), 5794-5813.
3. Werley C.A.*, Chien M.P.*, Gaublomme J, Shekhar K., Yi A., Bloxham W., Regev A., Cohen A. “Geometry-dependent maturation of iPSC-derived cardiomyocytes probed by simultaneous voltage and calcium imaging with genetically encoded fluorescent sensors.” PLOS One, 2017, 12(3):e0172671.
4. Chien M.P., Werley C.A., Farhi S.L., Cohen A. E. “Photostick: a method for selective isolation of target cells from culture.” Chemical Science, 2015; 6: 1701-1705.
5. Nguyen M.M., Carlini A.S., Chien M.P., Sonnenberg S., Luo C., Braden R.L., Osborn K.G., Li Y, Gianneschi N.C., Christman K.L. “Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.” Advanced Materials. 2015, 37: 5547-52.
6. Proetto M.T., Rush A.M., Chien M.P., Baeza P.A., Thompson M.P., Olson N.H., Andolina C., Millstone J., Moore C.E., Rheingold A.L., Howell S.B., Browning N.D., Evans J.E., Gianneschi N.C. “Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water.” J Am Chem Soc. 2014 Jan 29;136(4):1162-5.
7. Chien M.P., Hu D., Barback C.V., Rush A.M., Orr G., Hall D.J., and Gianneschi N. C. “Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by In Vivo Whole Animal and Ex Vivo Super Resolution Fluorescence Imaging.” J Am Chem Soc. 2013 Dec 18;135(50):18710-3.
8. Chien M.P., Thompson M.P., Ku T.H., Barback C. and Gianneschi N. C. “Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue.” Advanced Materials. 2013, July 12 (25): 3599-3604.
9. Chien M.P., Thompson M.P., Eugene C. Lin, and Gianneschi N.C. “Fluorogenic Enzyme-Responsive Micellar Nanoparticles.” Chemical Science. 2012, 3: 2690-2694. (Cover Art)
10. Randolph L.M.*, Chien M.P.*, and Gianneschi N.C. “Biological Stimuli and Biomolecules in the Assembly and Manipulation of Nanoscale Polymeric Particles.” Chemical Science. 2012, 3(5). doi: 10.1039/C2SC00857B.
11. Chien M.P. and Gianneschi N.C. “A morphology-dependent bio-organic template for inorganic nanowire synthesis.” Small. 2011 Jul 18;7(14):2041-6.
12. Ku T.H.*, Chien M.P.*, Thompson M.P., Sinkovits R.S., Olson N.H., Baker T.S. and Gianneschi N.C. “Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes.” J Am Chem Soc. 2011 Jun 8;133(22):8392-5. (Cover Art)
13. Kinsella J.M., Ananda S., Andrew J.S., Grondek J.F., Chien M.P., Scadeng M., Gianneschi N.C., Ruoslahti E., Sailor M.J. “Enhanced magnetic resonance contrast of fe(3)o(4) nanoparticles trapped in a porous silicon nanoparticle host.” Advanced Materials. 2011 Sep 22;23(36):H248-53.
14. Chien M.P., Thompson M.P., Gianneschi N.C. “DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes.” Chem. Commun. 2011. (Cover Art)
15. Chien M.P., Rush A.M., Thompson M.P., and Gianneschi N.C. “Programmable phase shifting micelles.” Angew. Chem. Int. Ed. Engl. 2010 Jul 12;49(30):5076-80. (Cover Art). Selected for Faculty of 1000 Biology.
16. Thompson M.P.*, Chien M.P.*, Ku T.H., Rush A.M., Gianneschi N.C. “Smart lipids for programmable nanomaterials.” Nano Lett. 2010 Jul 14;10(7):2690-3.
17. Jiang S., Chien M.P. and Chang D.K. “The fusion peptide domain is the primary membrane-inserted region and enhances membrane interaction of the ectodomain of HIV-1 gp41.” Mol. Membr. Biol. 2010 Jan;27(1):32-49.
18. Chien M.P., Lin C.H. and Chang D.K. “Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence.” Retrovirology, 2009 Mar 2;6:20.
19. Chien M.P., Jiang S. and Chang D.K. “The function of coreceptor as a basis for the kinetic dissection of human immunodeficiency virus type 1 Env-mediated cell fusion.” FASEB Journal, 2008 Apr;22(4):1179-92.
(* joint first author)
1. You L.*, Su P.-R.*, Betjes M*. Ghadiri Rad, R., Chou, T.-C., Beerens, C., van Oosten, E., Leufkens, F., Gasecka, P., Muraro, M., van Tol, R., van Steenderen, D., Farooq, S., Hardillo, J., Baatenburg de Jong, R., Brinks, D., Chien, M.-P. "Functional single cell selection and annotated profiling of dynamically changing cancer cells." Accepted, Nature Biomedical Engineering.
2. Li L., Ugalde A. P., Scheele C. LGJ, Dieter S. M., Nagel R., Ma J., Pataskar, A., Korkmaz, G., Elkon R., Chien M.P., You L., Su P. R., Bleijerveld O. B., Altelaar, M., Momchev L., Manber Z., Han R., van Breugel P. C., Lopes R., ten Dijke P., van Rheenen J., Agami R. "A Comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis." Genome Biology, 2021, In press.
Postdoctoral and graduate
(* joint first author)
1. Chien M.P.*, Brinks D.*, Adam, Y., Bloxham, W., Kheifets, S., Cohen A.E. “Two-photon photoactivated voltage imaging in brain tissue.” Science Advances, 2021, In press (BioRxiv, doi: https://doi.org/10.1101/211946)
2. Werley C.A., Chien M.P., Cohen A.E. “An ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation.” Biomedical Optics Express. 2017, 8(12), 5794-5813.
3. Werley C.A.*, Chien M.P.*, Gaublomme J, Shekhar K., Yi A., Bloxham W., Regev A., Cohen A. “Geometry-dependent maturation of iPSC-derived cardiomyocytes probed by simultaneous voltage and calcium imaging with genetically encoded fluorescent sensors.” PLOS One, 2017, 12(3):e0172671.
4. Chien M.P., Werley C.A., Farhi S.L., Cohen A. E. “Photostick: a method for selective isolation of target cells from culture.” Chemical Science, 2015; 6: 1701-1705.
5. Nguyen M.M., Carlini A.S., Chien M.P., Sonnenberg S., Luo C., Braden R.L., Osborn K.G., Li Y, Gianneschi N.C., Christman K.L. “Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.” Advanced Materials. 2015, 37: 5547-52.
6. Proetto M.T., Rush A.M., Chien M.P., Baeza P.A., Thompson M.P., Olson N.H., Andolina C., Millstone J., Moore C.E., Rheingold A.L., Howell S.B., Browning N.D., Evans J.E., Gianneschi N.C. “Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water.” J Am Chem Soc. 2014 Jan 29;136(4):1162-5.
7. Chien M.P., Hu D., Barback C.V., Rush A.M., Orr G., Hall D.J., and Gianneschi N. C. “Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by In Vivo Whole Animal and Ex Vivo Super Resolution Fluorescence Imaging.” J Am Chem Soc. 2013 Dec 18;135(50):18710-3.
8. Chien M.P., Thompson M.P., Ku T.H., Barback C. and Gianneschi N. C. “Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue.” Advanced Materials. 2013, July 12 (25): 3599-3604.
9. Chien M.P., Thompson M.P., Eugene C. Lin, and Gianneschi N.C. “Fluorogenic Enzyme-Responsive Micellar Nanoparticles.” Chemical Science. 2012, 3: 2690-2694. (Cover Art)
10. Randolph L.M.*, Chien M.P.*, and Gianneschi N.C. “Biological Stimuli and Biomolecules in the Assembly and Manipulation of Nanoscale Polymeric Particles.” Chemical Science. 2012, 3(5). doi: 10.1039/C2SC00857B.
11. Chien M.P. and Gianneschi N.C. “A morphology-dependent bio-organic template for inorganic nanowire synthesis.” Small. 2011 Jul 18;7(14):2041-6.
12. Ku T.H.*, Chien M.P.*, Thompson M.P., Sinkovits R.S., Olson N.H., Baker T.S. and Gianneschi N.C. “Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes.” J Am Chem Soc. 2011 Jun 8;133(22):8392-5. (Cover Art)
13. Kinsella J.M., Ananda S., Andrew J.S., Grondek J.F., Chien M.P., Scadeng M., Gianneschi N.C., Ruoslahti E., Sailor M.J. “Enhanced magnetic resonance contrast of fe(3)o(4) nanoparticles trapped in a porous silicon nanoparticle host.” Advanced Materials. 2011 Sep 22;23(36):H248-53.
14. Chien M.P., Thompson M.P., Gianneschi N.C. “DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes.” Chem. Commun. 2011. (Cover Art)
15. Chien M.P., Rush A.M., Thompson M.P., and Gianneschi N.C. “Programmable phase shifting micelles.” Angew. Chem. Int. Ed. Engl. 2010 Jul 12;49(30):5076-80. (Cover Art). Selected for Faculty of 1000 Biology.
16. Thompson M.P.*, Chien M.P.*, Ku T.H., Rush A.M., Gianneschi N.C. “Smart lipids for programmable nanomaterials.” Nano Lett. 2010 Jul 14;10(7):2690-3.
17. Jiang S., Chien M.P. and Chang D.K. “The fusion peptide domain is the primary membrane-inserted region and enhances membrane interaction of the ectodomain of HIV-1 gp41.” Mol. Membr. Biol. 2010 Jan;27(1):32-49.
18. Chien M.P., Lin C.H. and Chang D.K. “Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence.” Retrovirology, 2009 Mar 2;6:20.
19. Chien M.P., Jiang S. and Chang D.K. “The function of coreceptor as a basis for the kinetic dissection of human immunodeficiency virus type 1 Env-mediated cell fusion.” FASEB Journal, 2008 Apr;22(4):1179-92.
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